I am on Sertraline for a long time and cannot get any sensation in my penis during intercourse. I don’t suffer from problem in erection. I cannot change medicines so can I take anything before intercourse? Answer: Not able to feel sensation in penis could be a side effect of the drug. We call it the ‘lost penis syndrome’. Sertraline is an anti-depressant and belongs to a class of drug that is notorious for many sexual side effects. It is possible to switch to other drugs that have fewer sexual side effects provided your doctor who is responsible for prescribing